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Identification of Novel Disease Markers Using Depression Patient-Derived iPSCs

To establish a next-generation translational research platform for depression by
integrating patient-derived iPSC and brain organoid technologies, enabling precision diagnosis and personalized treatment while

advancing global leadership in mental health research.

KEYWORDKeyword

Depression iPSC Brain Organoid Biomarker Discovery Precision Psychiatry E-I Balance Multi-omics Drug Screening

OBJECTIVE Objective

This project aims to identify disease-specific biomarkers using patient-derived iPSC and brain organoid models of depression and
to establish a biologically informed classification system reflecting patient heterogeneity.
We further seek to elucidate excitatory/inhibitory (E/I) circuit imbalance and its molecular mechanisms,
ultimately developing a platform for therapeutic evaluation and drug screening toward precision psychiatry.

INTRODUCTION Director's Message



Despite its enormous societal burden, depression still lacks objective diagnostic biomarkers and effective patient stratification strategies.

By leveraging patient-derived iPSC and brain organoid technologies, our team aims to uncover the biological mechanisms underlying depression in
human neural systems and identify novel biomarkers and therapeutic opportunities.

Through close collaboration among KAIST, KIST, and Daegu Haany University,
we will establish an innovative translational platform bridging basic science and clinical application.





IMPACT Impact

This project will provide a foundation for objective biomarker discovery and
biologically informed patient stratification in depression.
In addition, the development of a brain organoid-based platform for therapeutic evaluation and
drug screening is expected to accelerate psychiatric drug development and
contribute to innovation in the bio-healthcare industry.
Through the collaborative efforts of KAIST, KIST, and Daegu Haany University,
the project will also foster the next generation of interdisciplinary researchers
in precision psychiatry and promote the translation of basic discoveries into clinical applications.

TALENT Ideal Talent

We aim to train creative and highly motivated researchers capable of integrating stem cell biology, neuroscience,
organoid technologies, multi-omics analyses, and translational research.

Our program emphasizes collaboration, global engagement, and problem-solving skills
that transform fundamental discoveries into practical healthcare innovations.

FACULTY Faculty